We investigate the \emph{algebraic} reasoning of quantum programs inspired by the success of classical program analysis based on Kleene algebra. One prominent example of such is the famous Kleene Algebra with Tests (KAT), which has furnished both theoretical insights and practical tools. The succinctness of algebraic reasoning would be especially desirable for scalable analysis of quantum programs, given the involvement of exponential-size matrices in most of the existing methods. A few key features of KAT including the idempotent law and the nice properties of classical tests, however, fail to hold in the context of quantum programs due to their unique quantum features, especially in branching. We propose the Non-idempotent Kleena Algebra (NKA) as a natural alternative, and identify complete and sound semantic models for NKA as well as their appropriate quantum interpretations. In light of applications of KAT, we are able to demonstrate algebraic proofs in NKA of quantum compiler optimization and the normal form of quantum \textbf{while}-programs.